IRAK1

IRAK1
interleukin-1 receptor-associated kinase 1
Обозначения
Символы IRAK1
Entrez Gene 3654
HGNC 6112
OMIM 300283
RefSeq NM_001025242
UniProt P51617
Другие данные
Локус X-хр., Xq28
Активация липополисахаридным рецепторным комплексом CD14/TLR4/MD2 фактора трансрипции NFkB.

IRAK1 (англ. interleukin-1 receptor-associated kinase 1) — цитозольная киназа, относящаяся к группе IRAK. Участвует в передаче сигнала от рецептора интерлейкина-1 (тип I) и некоторых толл-подобных рецепторов. Содержит магний в качестве кофактора. Открыта в 1996 году.

См. также

Литература

  • Ringwood L, Li L (April 2008). «The involvement of the interleukin-1 receptor-associated kinases (IRAKs) in cellular signaling networks controlling inflammation». Cytokine 42 (1): 1–7. DOI:10.1016/j.cyto.2007.12.012. PMID 18249132.



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