self-antigen
21major histocompatibility antigen — A cell surface protein or glycoprotein that allows the immune system to distinguish foreign or non self from self . A better term is histoglobulin. These are the antigens that must be matched between donors and recipients during organ and tissue… …
22Cytotoxic T cell — Antigen presentation stimulates T cells to become either cytotoxic CD8+ cells or helper CD4+ cells. A cytotoxic T cell (also known as TC, Cytotoxic T Lymphocyte, CTL, T Killer cell, cytolytic T cell, CD8+ T cells or killer T cell) belongs to a… …
23immune system disorder — Introduction Disorders of the immune systemany of various failures in the body s defense mechanisms against infectious organisms (see table (Disorders of the immune system)). Disorders of immunity include immune deficiency diseases, such… …
24Central tolerance — is the mechanism by which newly developing T cells and B cells are rendered non reactive to self[1]. The concept of central tolerance was proposed in 1959 by Joshua Lederberg[2], as part of his general theory of immunity and tolerance, and is… …
25Molecular mimicry — is defined as the theoretical possibility that sequence similarities between foreign and self peptides are sufficient to result in the cross activation of autoreactive T or B cells by pathogen derived peptides. Despite the promiscuity of several… …
26T cell — T cells belong to a group of white blood cells known as lymphocytes, and play a central role in cell mediated immunity. They can be distinguished from other lymphocyte types, such as B cells and natural killer cells by the presence of a special… …
27Protective autoimmunity — is a condition in which cells of the adaptive immune system contribute to maintenance of the functional integrity of a tissue, or facilitate its repair following an insult. The term ‘protective autoimmunity’ was coined by Prof. Michal Schwartz of …
28human disease — Introduction an impairment of the normal state of a human being that interrupts or modifies its vital functions. health versus disease Before human disease can be discussed, the meanings of the terms health, physical fitness, illness …
29B cell — B cells are lymphocytes that play a large role in the humoral immune response (as opposed to the cell mediated immune response, which is governed by T cells). The principal functions of B cells are to make antibodies against antigens, perform the …
30MHC restriction — MHC restricted antigen recognition, or MHC restriction, refers to the fact that a given T cell will recognize a peptide antigen only when it is bound to a particular MHC molecule. Normally, as T cells are stimulated only in the presence of self… …
