double-stranded break
41Okazaki fragments — DNA replication Okazaki fragments are short molecules of single stranded DNA that are formed on the lagging strand during DNA replication. They are between 1,000 to 2,000 nucleotides long in Escherichia coli and are between 100 to 200 nucleotides …
42Genetics — This article is about the general scientific term. For the scientific journal, see Genetics (journal). Part of a series on Genetics Key components Chromosome DNA • RNA Genome …
43Deoxyribonuclease — Crystals of DNase protein. A deoxyribonuclease (DNase, for short) is any enzyme that catalyzes the hydrolytic cleavage of phosphodiester linkages in the DNA backbone. Thus, deoxyribonucleases are one type of nuclease. A wide variety of… …
44nick — In molecular biology, a hydrolytic cleavage of a phosphodiester bond in one strand of a double stranded polynucleic acid. Cf.:cut. * * * nick nik n a break in one strand of two stranded DNA caused by a missing phosphodiester bond nick …
45DNA glycosylase — DNA glycosylases are a family of enzymes involved in base excision repair, classified under EC number EC 3.2.2. Base excision repair is the mechanism by which damaged bases in DNA are removed and replaced. DNA glycosylases catalyze the first step …
46Ku (protein) — Ku is a protein that binds to DNA double strand break ends and is required for the non homologous end joining (NHEJ) pathway of DNA repair. Ku is evolutionarily conserved from bacteria to human. The ancestral bacterial Ku is a homodimer (two… …
47Lambda phage — Taxobox color = violet name = Enterobacteria phage λ image width = 200px image caption = virus group = I ordo = Caudovirales familia = Siphoviridae subfamily = genus = λ like viruses species = λ Phage Enterobacteria phage λ (lambda phage) is a… …
48Heteroduplex — A heteroduplex is a double stranded (duplex) molecule of nucleic acid originated through the genetic recombination of single complementary strands derived from different sources, such as from different homologous chromosomes or even from… …
49Nucleic acid hybridization — Hybridization is the process, discovered by Alexander Rich, of combining complementary, single stranded nucleic acids into a single molecule. Nucleotides will bind to their complement under normal conditions, so two perfectly complementary… …
50Base excision repair — (BER) is a cellular mechanism that repairs damaged DNA throughout the cell cycle. Repairing DNA sequence errors is necessary so that mutations are not propagated or to remove lesions that may lead to breaks in the DNA during replication.Single… …
