T-box, brain, 1

T-box, brain, 1
[[Изображение:|px|TBR1 chemical structure]]
TBR1
Обозначения
Symbol(s) TBR1
Entrez 10716
OMIM 604616
RefSeq NM_006593
UniProt Q16650
PDB [1]
Другие данные
Шифр КФ [2]
Локус Хр. 2 q24.2

T-box, brain, 1, или TBR1 — фактор транскрипции семейства T-box, впервые описанный в 1995 году.[1] Белки TBR1 у мыши и человека имеют схожую структуру и оба в значительной степени гомологичны продукту гена Brachyury. TBR1 может действовать в союзе с CASK, контролируя транскрипцию генов, содержащих T-элемент, в том числе RELN и [2] Точечное нарушение гена TBR1 у мышей приводит к [3]


Примечания

  1. Bulfone A, Smiga SM, Shimamura K, Peterson A, Puelles L, Rubenstein JL (July 1995). "T-brain-1: a homolog of Brachyury whose expression defines molecularly distinct domains within the cerebral cortex". Neuron 15 (1): 63–78. PMID 7619531.
  2. Wang GS, Hong CJ, Yen TY, Huang HY, Ou Y, Huang TN, Jung WG, Kuo TY, Sheng M, Wang TF, Hsueh YP (April 2004). "Transcriptional modification by a CASK-interacting nucleosome assembly protein". Neuron 42 (1): 113–28. PMID 15066269.
  3. Hevner RF, Shi L, Justice N, Hsueh Y, Sheng M, Smiga S, Bulfone A, Goffinet AM, Campagnoni AT, Rubenstein JL (February 2001). "Tbr1 regulates differentiation of the preplate and layer 6". Neuron 29 (2): 353–66. PMID 11239428.

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