- Imidazoline receptor
Imidazoline receptors are receptors for
clonidine and otherimidazoline s.cite journal | author = Head GA, Mayorov DN | title = Imidazoline receptors, novel agents and therapeutic potential | journal = Cardiovasc Hematol Agents Med Chem | volume = 4 | issue = 1 | pages = 17–32 | year = 2006 | month = January | pmid = 16529547 | url = http://www.bentham-direct.org/pages/content.php?CHAMC/2006/00000004/00000001/003AE.SGM | issn = ]Classes
There are three classes of imidazoline receptors:
* I1 receptor – mediates the sympatho-inhibitory actions of imidazolines to lower blood pressure, (NISCH or IRAS, imidazoline receptor antisera selected)
* I2 receptor – an allosteric binding site ofmonoamine oxidase
* I3 receptor – regulatesinsulin secretion from pancreaticbeta cell sActivated I1-imidazoline receptors trigger the hydrolysis of
phosphatidylcholine into DAG. Elevated DAG levels in turn trigger the synthesis of second messengersarachidonic acid and downstreameicosanoids .cite journal | author = Ernsberger P | title = The I1-imidazoline receptor and its cellular signaling pathways | journal = Ann. N. Y. Acad. Sci. | volume = 881 | issue = | pages = 35–53 | year = 1999 | month = June | pmid = 10415895 | url = http://www.annalsnyas.org/cgi/content/abstract/881/1/35 | issn = ] In addition, thesodium-hydrogen antiporter is inhibited, and enzymes ofcatecholamine synthesis is induced. The I1-imidazoline receptor may belong to theneurocytokine receptor family, since its signaling pathways are similar to those ofinterleukin s.Pharmacology
Agonist s of these receptors include theantihypertensive moxonidine , while antagonists includeidazoxan .ee also
*
imidazoline
*NISCH References
External links
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