VUF-6002

VUF-6002

Drugbox
IUPAC_name = 1- [(5-Chloro-1H-benzimidazol-2-yl)carbonyl] -4-methylpiperazine



CAS_number= 869497-75-6
ATC_prefix=
ATC_suffix=
PubChem= 10446295
DrugBank=
C=13 | H=15 | Cl=1 | N=4 | O=1
molecular_weight = 278.737 g/mol
smiles = n2c1ccc(Cl)cc1nc2C(=O)N3CCN(C)CC3
bioavailability=
metabolism =
elimination_half-life=
excretion =
pregnancy_category =
legal_status =
routes_of_administration=

VUF-6002 (JNJ 10191584) is a drug which acts as a potent and selective antagonist at the histamine H4 receptor. [Zhang M, Thurmond RL, Dunford PJ. The histamine H(4) receptor: a novel modulator of inflammatory and immune disorders. "Pharmacology and Therapeutics". 2007 Mar;113(3):594-606. PMID 17275092] It has antiinflammatory and analgesic effects in animal studies of acute inflammation. [Coruzzi G, Adami M, Guaita E, de Esch IJ, Leurs R. Antiinflammatory and antinociceptive effects of the selective histamine H4-receptor antagonists JNJ7777120 and VUF6002 in a rat model of carrageenan-induced acute inflammation. "European Journal of Pharmacology". 2007 Jun 1;563(1-3):240-4. PMID 17382315]

References


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать курсовую

Look at other dictionaries:

  • Histamine H4 receptor — protein Name=histamine receptor H4 caption= width= HGNCid=17383 Symbol=HRH4 AltSymbols= EntrezGene=59340 OMIM=606792 RefSeq=NM 021624 UniProt=Q9H3N8 PDB= ECnumber= Chromosome=18 Arm=q Band=11.2 LocusSupplementaryData=The histamine H4 receptor is …   Wikipedia

  • Clozapine — Not to be confused with clonazepam or Klonopin. Clozapine Systematic (IUPAC) name …   Wikipedia

  • Trifluoperazine — Systematic (IUPAC) name 10 [3 (4 methylpiperazin 1 yl)propyl] 2 (trifluoromethyl) 10H phenothiazine Clinical data AHFS/ …   Wikipedia

  • Fluphenazine — Systematic (IUPAC) name 2 [4 [3 [2 (trifluoromethyl) 10H phenothiazin 10 yl]propyl]piperazin 1 yl]ethanol Clinical data …   Wikipedia

  • Olanzapine — Systematic (IUPAC) name 2 methyl 4 (4 methyl …   Wikipedia

  • Perphenazine — Systematic (IUPAC) name 2 [4 [3 (2 chloro 10H phenothiazin 10 yl) propyl]piperazin 1 yl]ethanol Clinical data AHFS/Drugs.com …   Wikipedia

  • Aripiprazole — Systematic (IUPAC) name 7 {4 [4 (2,3 dichlorophenyl)piperazin 1 yl]butoxy} 3,4 dihydroquinolin 2(1H) one Clinical data Trade names …   Wikipedia

  • Loxapine — Systematic (IUPAC) name 2 Chloro 11 (4 methylpiperazin 1 yl)dibenzo[b,f][1,4]oxazepine Clinical data AHFS/Drugs.com …   Wikipedia

  • Hydroxyzine — Systematic (IUPAC) name (±) 2 (2 {4 [(4 chlorophenyl) phe …   Wikipedia

  • Amoxapine — Systematic (IUPAC) name 2 Chloro 11 (piperazin 1 yl)dibenzo[b,f][1,4]oxazepine Clinical data Trade names Asendin …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”